Article
PD-1 Expression on CD8+CD28- T cells within inflammatory synovium is associated with Relapse: A cohort of Rheumatoid Arthritis.
Immunology letters - 1 Dec 2020
Ajam Faezeh, Aghaei Mehrdad, Mohammadi Saeed, Samiei Hadiseh, Behnampour Nasser, Memarian Ali
Abstract excerpt
Defect in T lymphocyte homeostasis could implicate initiation and development of rheumatoid arthritis (RA). Since PD-1 plays a key role in the regulation of T lymphocytes, its expression pattern in various CD8+ T cell subsets could be so effective in RA pathogenesis. Here, we investigated the expression of PD-1 and CXCR3 on CD8+CD28- T cells in association with the IFN-γ levels in patients with RA. A total of 42...
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