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Article

T helper cells in synovial fluid of patients with rheumatoid arthritis primarily have a Th1 and a CXCR3+Th2 phenotype.

Arthritis research & therapy - 16 Oct 2020

Aldridge Jonathan, Ekwall Anna-Karin H, Mark Linda, Bergström Beatrice, Andersson Kerstin, Gjertsson Inger, Lundell Anna-Carin, Rudin Anna

Abstract excerpt

BACKGROUND: The majority of CD4+ T helper (Th) cells found in the synovial fluid (SF) of patients with rheumatoid arthritis (RA) express CXCR3, a receptor associated with Th1 cells. In blood, subsets of Th2 and Th17 cells also express CXCR3, but it is unknown if these cells are present in RA SF or how cytokines from these subsets affect cytokine/chemokine secretion by fibroblast-like synoviocytes (FLS) from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33066816
DOI: 10.1186/s13075-020-02349-y
PMCID: PMC7566124

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