Article
Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness.
mBio - 31 Aug 2021
Mortier Julien, Gayán Elisa, Van Eyken Ronald, Torres Montaguth Oscar Enrique, Khodaparast Ladan, Khodaparast Laleh, Houben Bert, Carpentier Sebastien, Rousseau Frederic, Schymkowitz Joost, Aertsen Abram
Abstract excerpt
Despite our extensive knowledge of the genetic regulation of heat shock proteins (HSPs), the evolutionary routes that allow bacteria to adaptively tune their HSP levels and corresponding proteostatic robustness have been explored less. In this report, directed evolution experiments using the Escherichia coli model system unexpectedly revealed that seemingly random single mutations in its tnaA gene can confer...
Topics
- Alleles
- Directed Molecular Evolution
- Escherichia coli
- Gain of Function Mutation
- Gene Expression Regulation, Bacterial
- Genetic Fitness
- Heat-Shock Proteins
- Heat-Shock Response
- Mutation