Bacterial Hsp90 predominantly buffers but does not potentiate the phenotypic effects of deleterious mutations during fluorescent protein evolution.

Abstract excerpt

Chaperones facilitate the folding of other ("client") proteins and can thus affect the adaptive evolution of these clients. Specifically, chaperones affect the phenotype of proteins via two opposing mechanisms. On the one hand, they can buffer the effects of mutations in proteins and thus help preserve an ancestral, premutation phenotype. On the other hand, they can potentiate the effects of mutations and thus...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacteria
• Share to Green Fluorescent Proteins
• Share to HSP90 Heat-Shock Proteins