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Article

Technical and biological constraints on ctDNA-based genotyping.

Trends in cancer - 1 Nov 2021

Herberts Cameron, Wyatt Alexander W

Abstract excerpt

Circulating tumor DNA (ctDNA) enables real-time genomic profiling of cancer without the need for tissue biopsy. ctDNA-based technology is seeing rapid uptake in clinical practice due to the potential to inform patient management from diagnosis to advanced disease. In metastatic disease, ctDNA can identify somatic mutations, copy-number variants (CNVs), and structural rearrangements that are predictive of therapy...

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PMID: 34219051
DOI: 10.1016/j.trecan.2021.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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