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Article

Circulating Tumor DNA Testing for Homology Recombination Repair Genes in Prostate Cancer: From the Lab to the Clinic.

International journal of molecular sciences - 24 May 2021

Cimadamore Alessia, Cheng Liang, Massari Francesco, Santoni Matteo, Pepi Laura, Franzese Carmine, Scarpelli Marina, Lopez-Beltran Antonio, Galosi Andrea Benedetto, Montironi Rodolfo

Abstract excerpt

Approximately 23% of metastatic castration-resistant prostate cancers (mCRPC) harbor deleterious aberrations in DNA repair genes. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) therapy has shown improvements in overall survival in patients with mCRPC who harbor somatic and/or germline alterations of homology recombination repair (HRR) genes. Peripheral blood samples are typically used for the germline...

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Identifiers

PMID: 34073818
DOI: 10.3390/ijms22115522
PMCID: PMC8197269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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