Article
Inhibition of EZH2 prevents acute respiratory distress syndrome (ARDS)-associated pulmonary fibrosis by regulating the macrophage polarization phenotype.
Respiratory research - 3 Jul 2021
Bao Xiaowei, Liu Xiandong, Liu Na, Zhuang Shougang, Yang Qian, Ren Huijuan, Zhao Dongyang, Bai Jianwen, Zhou Xiaohui, Tang Lunxian
Abstract excerpt
BACKGROUND: We recently reported histone methyltransferase enhancer of zeste homolog 2 (EZH2) as a key epigenetic regulator that contributes to the dysfunction of innate immune responses to sepsis and subsequent lung injury by mediating the imbalance of macrophage polarization. However, the role of EZH2 in acute respiratory distress syndrome (ARDS)-associated fibrosis remains poorly understood. METHODS: In this...
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