Article
A state-of-the-art review of stratified medicine in cancer: towards a future precision medicine strategy in cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Feb 2022
Middleton G, Robbins H, Andre F, Swanton C
Abstract excerpt
BACKGROUND: Building on the success of targeted therapy in certain well-defined cancer genotypes, three platform studies-NCI-MATCH, LUNG-MAP and The National Lung Matrix Trial (NLMT)-have attempted to discover new genotype-matched therapies for people with cancer. PATIENTS AND METHODS: We review the outputs from these platform studies. This review led us to propose a series of recommendations and considerations...
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