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Application of genotype-guided cancer therapy in solid tumors.

Pharmacogenomics - 1 Jan 2014

Patel Jai N

Abstract excerpt

Given the interpatient biological heterogeneity and narrow therapeutic index of anticancer drugs, a practical method for personalizing cancer therapy is essential. Genotype-guided cancer therapy will provide an optimal approach to normalize systemic drug exposures, predict drug toxicities and/or enrich clinical efficacy. To date, over a dozen anticancer drugs approved by the US FDA require labeling regarding...

Topics

Antineoplastic Agents
Biomarkers, Tumor
Genotype
Humans
Neoplasms
Pharmacogenetics
Precision Medicine
Translational Research, Biomedical

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24329193
DOI: 10.2217/pgs.13.227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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