Article
Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism.
Neuroscience letters - 11 Sept 2003
Dekker Marieke C J, Giesbergen Patricia C, Njajou Omer T, van Swieten John C, Hofman Albert, Breteler Monique M B, van Duijn Cornelia M
Abstract excerpt
Iron overload increases oxidative stress and may lead to neurodegenerative disease like Parkinson's disease (PD). We studied the role of mutations in the hemochromatosis gene HFE in PD and other parkinsonism (non-PD PS) in two population-based series. The first series consisted of 137 patients with PD and 47 with non-PD PS, and the second of 60 patients with PD and 25 with non-PD PS. In the first series, PD...
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