Association study between four polymorphisms in the HFE, TF and TFR genes and Parkinson's disease in southern Italy.

doi:10.1007/s10072-011-0504-9

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Article

Association study between four polymorphisms in the HFE, TF and TFR genes and Parkinson's disease in southern Italy.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Jun 2011

Greco Valentina, De Marco Elvira Valeria, Rocca Francesca Emanuela, Annesi Ferdinanda, Civitelli Donatella, Provenzano Giovanni, Tarantino Patrizia, Scornaienchi Vittorio, Pucci Franco, Salsone Maria, Novellino Fabiana, Morelli Maurizio, Paglionico Sandra, Gambardella Antonio, Quattrone Aldo, Annesi Grazia

Abstract excerpt

Iron overload may lead to neurodegenerative disorders such as Parkinson's disease (PD) and alterations of iron-related genes might be involved in the pathogenesis of this disease. The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF). We examined four known polymorphisms, C282Y and H63D in the HFE gene,...

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PMID: 21384276
DOI: 10.1007/s10072-011-0504-9

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