Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance.

doi:10.1038/s42003-021-02279-8

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Article

Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance.

Communications biology - 1 Jul 2021

Schumann Tina, König Jörg, von Loeffelholz Christian, Vatner Daniel F, Zhang Dongyan, Perry Rachel J, Bernier Michel, Chami Jason, Henke Christine, Kurzbach Anica, El-Agroudy Nermeen N, Willmes Diana M, Pesta Dominik, de Cabo Rafael, O Sullivan John F, Simon Eric, Shulman Gerald I, Hamilton Bradford S, Birkenfeld Andreas L

Abstract excerpt

Genome-wide association studies have identified SLC16A13 as a novel susceptibility gene for type 2 diabetes. The SLC16A13 gene encodes SLC16A13/MCT13, a member of the solute carrier 16 family of monocarboxylate transporters. Despite its potential importance to diabetes development, the physiological function of SLC16A13 is unknown. Here, we validate Slc16a13 as a lactate transporter expressed at the plasma...

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PMID: 34211098
DOI: 10.1038/s42003-021-02279-8
PMCID: PMC8249653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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