Article

<i>Prdm16</i> mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators

2023-01-10

Abstract excerpt

<h4>Background</h4> Mutation of the PRDM16 gene has been associated with human cardiomyopathy. The PRDM16 protein is a transcriptional regulator affecting cardiac development via Tbx5 and Hand1 regulating myocardial structure. Biallelic Prdm16 inactivation induces severe cardiac dysfunction with postnatal lethality and hypertrophy in mice. Early pathological events upon Prdm16 inactivation have not been explor...

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Literature Corpus work: f0e3d688-2616-537e-8bd0-257c5cae3e33
DOI: 10.1101/2023.01.10.523243

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