Article
The diabetes susceptibility gene Clec16a regulates mitophagy.
Cell - 19 Jun 2014
Soleimanpour Scott A, Gupta Aditi, Bakay Marina, Ferrari Alana M, Groff David N, Fadista João, Spruce Lynn A, Kushner Jake A, Groop Leif, Seeholzer Steven H, Kaufman Brett A, Hakonarson Hakon, Stoffers Doris A
Abstract excerpt
Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the Nrdp1 target Parkin, a master regulator of mitophagy. Islets from mice with pancreas-specific...
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