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Article

Coexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets.

Neurological research - 1 Nov 2021

Ak Aksoy Secil, Mutlu Melis, Tunca Berrin, Kocaeli Hasan, Taskapilioglu Mevlut Ozgur, Bekar Ahmet, Tekin Cagla, Argadal Omer Gokay, Civan Muhammet Nafi, Kaya İsmail Seckin, Ocak Pınar Eser, Tolunay Sahsine

Abstract excerpt

Objective: This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogeneous subgroups.Methods: We analyzed the expression profiles of ATRX/DAXX and MALAT1 using the qRT-PCR method and IDH and TERT mutation status using DNA sequencing...

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Identifiers

PMID: 34210246
DOI: 10.1080/01616412.2021.1948738

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