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Article

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series

29 Jun 2021

Abstract excerpt

Current treatment options for visceral leishmaniasis have several drawbacks, and clinicians are confronted with an increasing number of treatment failures. To overcome this, the Drugs for Neglected Diseases initiative (DNDi) has invested in the development of novel antileishmanial leads, including a very promising class of oxaboroles. The mode of action/resistance of this series to Leishmania is still unknown and...

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PMID: 34210040
DOI: 10.3390/microorganisms9071408

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