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Article

CARD9 Deficiency Increases Hippocampal Injury Following Acute Neurotropic Picornavirus Infection but Does Not Affect Pathogen Elimination.

International journal of molecular sciences - 29 Jun 2021

Pavasutthipaisit Suvarin, Stoff Melanie, Ebbecke Tim, Ciurkiewicz Malgorzata, Mayer-Lambertz Sabine, Störk Theresa, Pavelko Kevin D, Lepenies Bernd, Beineke Andreas

Abstract excerpt

Neurotropic viruses target the brain and contribute to neurologic diseases. Caspase recruitment domain containing family member 9 (CARD9) controls protective immunity in a variety of infectious disorders. To investigate the effect of CARD9 in neurotropic virus infection, CARD9-/- and corresponding C57BL/6 wild-type control mice were infected with Theiler's murine encephalomyelitis virus (TMEV). Brain tissue was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34209576
DOI: 10.3390/ijms22136982
PMCID: PMC8268812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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