Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurons are MHC Class I-Dependent Targets for CD8 T Cells upon Neurotropic Viral Infection

17 Nov 2011

Abstract excerpt

Following infection of the central nervous system (CNS), the immune system is faced with the challenge of eliminating the pathogen without causing significant damage to neurons, which have limited capacities of renewal. In particular, it was thought that neurons were protected from direct attack by cytotoxic T lymphocytes (CTL) because they do not express major histocompatibility class I (MHC I) molecules, at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors
Share to Virology and Viral Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22114563
DOI: 10.1371/journal.ppat.1002393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurons are MHC Class I-Dependent Targets for CD8 T Cells upon Neurotropic Viral InfectionPMID 22114563Read ↗

The Role of CD8<sup>+</sup>T Cells and Major Histocompatibility Complex Class I Expression in the Central Nervous System of Mice Infected with Neurovirulent Sindbis VirusSemantic proximity Read ↗

Multimodal Profiling of Immune Responses Reveals Innate-Adaptive Immune Imbalance in Human Bornavirus EncephalitisSemantic proximity Read ↗

Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infectionSemantic proximity Read ↗

Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response.Semantic proximity Read ↗

KIR3DL1 and Tox identify clonally expanded encephalitogenic neuron-specific CD8+ T cells in autoimmune encephalitisSemantic proximity Read ↗

Infection and Injury of Neurons by West NileEncephalitisVirusSemantic proximity Read ↗

Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrainSemantic proximity Read ↗

Transcriptional Response to Tick-Borne Flavivirus Infection in Neurons, Astrocytes and Microglia In Vivo and In VitroSemantic proximity Read ↗

Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous SystemSemantic proximity Read ↗

Experimental encephalomyelitis at age 90, still relevant and elucidating how viruses trigger diseaseSemantic proximity Read ↗

Powassan Virus Induces Structural Changes in Human Neuronal Cells In Vitro and Murine Neurons In VivoSemantic proximity Read ↗

Viral vectors in neurodegenerative diseases: immune responses and therapeutic applicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.