Extrapulmonary Aspergillus infection in patients with CARD9 deficiency.

doi:10.1172/jci.insight.89890

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Article

Extrapulmonary Aspergillus infection in patients with CARD9 deficiency.

JCI insight - 20 Oct 2016

Rieber Nikolaus, Gazendam Roel P, Freeman Alexandra F, Hsu Amy P, Collar Amanda L, Sugui Janyce A, Drummond Rebecca A, Rongkavilit Chokechai, Hoffman Kevin, Henderson Carolyn, Clark Lily, Mezger Markus, Swamydas Muthulekha, Engeholm Maik, Schüle Rebecca, Neumayer Bettina, Ebel Frank, Mikelis Constantinos M, Pittaluga Stefania, Prasad Vinod K, Singh Anurag, Milner Joshua D, Williams Kelli W, Lim Jean K, Kwon-Chung Kyung J, Holland Steven M, Hartl Dominik, Kuijpers Taco W, Lionakis Michail S

Abstract excerpt

Invasive pulmonary aspergillosis is a life-threatening mycosis that only affects patients with immunosuppression, chemotherapy-induced neutropenia, transplantation, or congenital immunodeficiency. We studied the clinical, genetic, histological, and immunological features of 2 unrelated patients without known immunodeficiency who developed extrapulmonary invasive aspergillosis at the ages of 8 and 18. One patient...

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Identifiers

PMID: 27777981
DOI: 10.1172/jci.insight.89890
PMCID: PMC5070961

Genes

CARD9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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