Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modular Lentiviral Vectors for Highly Efficient Transgene Expression in Resting Immune Cells.

Viruses - 18 Jun 2021

Fichter Christina, Aggarwal Anupriya, Wong Andrew Kam Ho, McAllery Samantha, Mathivanan Vennila, Hao Bailey, MacRae Hugh, Churchill Melissa J, Gorry Paul R, Roche Michael, Gray Lachlan R, Turville Stuart

Abstract excerpt

Gene/cell therapies are promising strategies for the many presently incurable diseases. A key step in this process is the efficient delivery of genes and gene-editing enzymes to many cell types that may be resistant to lentiviral vector transduction. Herein we describe tuning of a lentiviral gene therapy platform to focus on genetic modifications of resting CD4+ T cells. The motivation for this was to find...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Gene Transfer Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to Lentivirus

Share to Resting Phase, Cell Cycle

Share to T-Lymphocytes

Share to Transduction, Genetic

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 34207354
DOI: 10.3390/v13061170
PMCID: PMC8235771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modular Lentiviral Vectors for Highly Efficient Transgene Expression in Resting Immune Cells.PMID 34207354Read ↗

Efficient delivery of lentiviral vectors into resting human CD4 T cellsSemantic proximity Read ↗

Genome editing for scalable production of alloantigen‐free lentiviral vectors for in vivo gene therapySemantic proximity Read ↗

Delivering genes with human immunodeficiency virus-derived vehicles: still state-of-the-art after 25 yearsSemantic proximity Read ↗

An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytesSemantic proximity Read ↗

Recent advances in lentiviral vector development and applications.Semantic proximity Read ↗

Hybrid ssDNA repair templates enable high yield genome engineering in primary cells for disease modeling and cell therapy manufacturingSemantic proximity Read ↗

HIV-1 vectors: fulfillment of expectations, further advancements, and still a way to go.Semantic proximity Read ↗

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analysesSemantic proximity Read ↗

Ultra-large targeted DNA integrations in primary human cellsSemantic proximity Read ↗

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails.Semantic proximity Read ↗

Lentiviral vectors for immunization: an inflammatory fieldSemantic proximity Read ↗

Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.