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Senescence and Aging: Does It Impact Cancer Immunotherapies?

22 Jun 2021

Abstract excerpt

Cancer incidence increases drastically with age. Of the many possible reasons for this, there is the accumulation of senescent cells in tissues and the loss of function and proliferation potential of immune cells, often referred to as immuno-senescence. Immune checkpoint inhibitors (ICI), by invigorating immune cells, have the potential to be a game-changers in the treatment of cancer. Yet, the variability in the...

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PMID: 34206425
DOI: 10.3390/cells10071568

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