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Immunosenescence promotes cancer development: from mechanisms to treatment strategies

10 Mar 2025

Abstract excerpt

The body’s innate immune system plays a pivotal role in identifying and eliminating cancer cells. However, as the immune system ages, its functionality can deteriorate, becoming dysfunctional, inefficient, or even inactive—a condition referred to as immunosenescence. This decline significantly increases the risk of malignancies. While the pro-cancer effects of T-cell aging have been widely explored, there remains...

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PMID: 40065335
DOI: 10.1186/s12964-025-02082-6

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