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Article

Telomere elongation chooses TERRA ALTernatives

9 Jul 2015

Abstract excerpt

Alternative Lengthening of Telomeres (ALT) mechanisms allow telomerase-negative immortal cells to buffer replicative telomere shortening. ALT is naturally active in a number of human cancers and might be selected upon telomerase inactivation. ALT is thought to operate through homologous recombination (HR) occurring between telomeric repeats from independent chromosome ends. Indeed, suppression of a number of HR...

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Identifiers

PMID: 26158306
DOI: 10.1080/15476286.2015.1065374

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