Transcription of telomeric DNA leads to high levels of homologous recombination and t-loops.

Abstract excerpt

The formation of DNA loops at chromosome ends (t-loops) and the transcription of telomeres producing G-rich RNA (TERRA) represent two central features of telomeres. To explore a possible link between them we employed artificial human telomeres containing long arrays of TTAGGG repeats flanked by the T7 or T3 promoters. Transcription of these DNAs generates a high frequency of t-loops within individual molecules...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Homologous Recombination
• Share to Mutation
• Share to Nucleic Acid Conformation