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Article

The Erns Carboxyterminus: Much More Than a Membrane Anchor.

Viruses - 23 Jun 2021

Tews Birke Andrea, Klingebeil Anne, Kühn Juliane, Franzke Kati, Rümenapf Till, Meyers Gregor

Abstract excerpt

Pestiviruses express the unique essential envelope protein Erns, which exhibits RNase activity, is attached to membranes by a long amphipathic helix, and is partially secreted from infected cells. The RNase activity of Erns is directly connected with pestivirus virulence. Formation of homodimers and secretion of the protein are hypothesized to be important for its role as a virulence factor, which impairs the...

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Identifiers

PMID: 34201636
DOI: 10.3390/v13071203
PMCID: PMC8310223

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