Fifty Shades of Erns: Innate Immune Evasion by the Viral Endonucleases of All Pestivirus Species.

doi:10.3390/v14020265

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Article

Fifty Shades of Erns: Innate Immune Evasion by the Viral Endonucleases of All Pestivirus Species.

Viruses - 27 Jan 2022

de Martin Elena, Schweizer Matthias

Abstract excerpt

The genus Pestivirus, family Flaviviridae, includes four historically accepted species, i.e., bovine viral diarrhea virus (BVDV)-1 and -2, classical swine fever virus (CSFV), and border disease virus (BDV). A large number of new pestivirus species were identified in recent years. A common feature of most members is the presence of two unique proteins, Npro and Erns, that pestiviruses evolved to regulate the...

Topics

Animals
Cell Line
Endocytosis
Endoribonucleases
Immune Evasion
Immunity, Innate
Interferons
Mutation
Myxovirus Resistance Proteins
Pestivirus
RNA, Double-Stranded
RNA, Viral
Viral Envelope Proteins

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Identifiers

PMID: 35215858
DOI: 10.3390/v14020265
PMCID: PMC8880635

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