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Charged Residues in the Membrane Anchor of the Pestiviral Erns Protein Are Important for Processing and Secretion of Erns and Recovery of Infectious Viruses.

Viruses - 10 Mar 2021

Oetter Kay-Marcus, Kühn Juliane, Meyers Gregor

Abstract excerpt

The pestivirus envelope protein Erns is anchored in membranes via a long amphipathic helix. Despite the unusual membrane topology of the Erns membrane anchor, it is cleaved from the following glycoprotein E1 by cellular signal peptidase. This was proposed to be enabled by a salt bridge-stabilized hairpin structure (so-called charge zipper) formed by conserved charged residues in the membrane anchor. We show here...

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PMID: 33801849
DOI: 10.3390/v13030444
PMCID: PMC8002126

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