Article
Effect of Infant and Maternal Secretor Status on Rotavirus Vaccine Take-An Overview.
Viruses - 14 Jun 2021
Sharma Sumit, Nordgren Johan
Abstract excerpt
Histo-blood group antigens, which are present on gut epithelial surfaces, function as receptors or attachment factors and mediate susceptibility to rotavirus infection. The major determinant for susceptibility is a functional FUT2 enzyme which mediates the presence of α-1,2 fucosylated blood group antigens in mucosa and secretions, yielding the secretor-positive phenotype. Secretors are more susceptible to...
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