Article
Host Genetic Susceptibility to Enteric Viruses: A Systematic Review and Metaanalysis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jan 2016
Kambhampati Anita, Payne Daniel C, Costantini Veronica, Lopman Benjamin A
Abstract excerpt
BACKGROUND: Norovirus and rotavirus are prominent enteric viruses responsible for severe acute gastroenteritis disease burden around the world. Both viruses recognize and bind to histo-blood group antigens, which are expressed by the fucosyltransferase 2 (FUT2) gene. Individuals with a functional FUT2 gene are termed "secretors." FUT2 polymorphisms may influence viral binding patterns and, therefore, may...
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