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Article

Vaccine Take of RV3-BB Rotavirus Vaccine Observed in Indonesian Infants Regardless of HBGA Status.

The Journal of infectious diseases - 12 Apr 2024

Donato Celeste M, Handley Amanda, Byars Sean G, Bogdanovic-Sakran Nada, Lyons Eleanor A, Watts Emma, Ong Darren S, Pavlic Daniel, At Thobari Jarir, Satria Cahya Dewi, Nirwati Hera, Soenarto Yati, Bines Julie E

Abstract excerpt

BACKGROUND: Histo-blood group antigen (HBGA) status may affect vaccine efficacy due to rotavirus strains binding to HBGAs in a P genotype-dependent manner. This study aimed to determine if HBGA status affected vaccine take of the G3P[6] neonatal vaccine RV3-BB. METHODS: DNA was extracted from stool samples collected in a subset (n = 164) of the RV3-BB phase IIb trial in Indonesian infants. FUT2 and FUT3 genes...

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Identifiers

PMID: 37592804
DOI: 10.1093/infdis/jiad351
PMCID: PMC11011179

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