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Article

The Lewis A phenotype is a restriction factor for Rotateq and Rotarix vaccine-take in Nicaraguan children.

Scientific reports - 24 Jan 2018

Bucardo Filemón, Nordgren Johan, Reyes Yaoska, Gonzalez Fredman, Sharma Sumit, Svensson Lennart

Abstract excerpt

Histo-blood group antigens (HBGAs) and the Lewis and secretor antigens are associated with susceptibility to rotavirus infection in a genotype-dependent manner. Nicaraguan children were prospectively enrolled in two cohorts vaccinated with either RotaTeq RV5 (n = 68) or Rotarix RV1 (n = 168). Lewis and secretor antigens were determined by saliva phenotyping and genotyping. Seroconversion was defined as a 4-fold...

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Identifiers

PMID: 29367698
DOI: 10.1038/s41598-018-19718-y
PMCID: PMC5784145

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ABO

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