Article

A common haplotype in the EXO5 gene can impact its protein structure and dynamics and modulate genome stability and cancer progression

2024-11-22

Abstract excerpt

Understanding the impact of common germline variants on protein structure, function, and disease progression is crucial in cancer research. This study presents a comprehensive analysis of the EXO5 gene, which encodes a DNA exonuclease involved in DNA repair previously associated with cancer susceptibility. We employed an integrated approach combining genomic and clinical data analysis, deep learning variant effect...

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Literature Corpus work: fcda9ff3-55e0-5f70-a6d1-0a0fc92a57fc
DOI: 10.1101/2024.11.22.623165

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