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Article

Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha.

The Journal of biological chemistry - 16 May 2003

Liu Chuan Yin, Xu Zhaohui, Kaufman Randal J

Abstract excerpt

Accumulation of unfolded proteins in the lumen of the endoplasmic reticulum activates a signal transduction cascade that culminates in the transcriptional induction of genes encoding adaptive functions. One proximal sensor for this unfolded protein response is the protein kinase/endoribonuclease IRE1alpha. IRE1alpha is a type-I transmembrane glycoprotein for which the N-terminal luminal domain (NLD) senses the...

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Identifiers

PMID: 12637535
DOI: 10.1074/jbc.M300418200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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