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Article

Genetic Analysis of Tryptophan Metabolism Genes in Sporadic Amyotrophic Lateral Sclerosis.

Frontiers in immunology - 1 Jan 2021

Fifita Jennifer A, Chan Moi Fat Sandrine, McCann Emily P, Williams Kelly L, Twine Natalie A, Bauer Denis C, Rowe Dominic B, Pamphlett Roger, Kiernan Matthew C, Tan Vanessa X, Blair Ian P, Guillemin Gilles J

Abstract excerpt

The essential amino acid tryptophan (TRP) is the initiating metabolite of the kynurenine pathway (KP), which can be upregulated by inflammatory conditions in cells. Neuroinflammation-triggered activation of the KP and excessive production of the KP metabolite quinolinic acid are common features of multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). In addition to its role in the...

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Identifiers

PMID: 34194442
DOI: 10.3389/fimmu.2021.701550
PMCID: PMC8236844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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