Article

An investigation of recent and novel genetic variants that are associated with the pathogenesis of amyotrophic lateral sclerosis and their implications on phenotypes of the disease

2014-01-01

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by loss of motor neurons in the spinal cord, brain stem and cerebral cortex. ALS is characterized by both upper and lower motor neuron symptoms and death usually occurs 3-5 years after onset. Familial histories are found in 5-10% of ALS cases while the rest are sporadic. This study is focused on analysing known and novel candidate genes in A...

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Literature Corpus work: 8eb41753-6d82-5e2f-882c-b2390f819f62
DOI: 10.25560/25531

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