Article
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
The Lancet. Neurology - 1 Oct 2010
Shatunov Aleksey, Mok Kin, Newhouse Stephen, Weale Michael E, Smith Bradley, Vance Caroline, Johnson Lauren, Veldink Jan H, van Es Michael A, van den Berg Leonard H, Robberecht Wim, Van Damme Philip, Hardiman Orla, Farmer Anne E, Lewis Cathryn M, Butler Amy W, Abel Olubunmi, Andersen Peter M, Fogh Isabella, Silani Vincenzo, Chiò Adriano, Traynor Bryan J, Melki Judith, Meininger Vincent, Landers John E, McGuffin Peter, Glass Jonathan D, Pall Hardev, Leigh P Nigel, Hardy John, Brown Robert H, Powell John F, Orrell Richard W, Morrison Karen E, Shaw Pamela J, Shaw Christopher E, Al-Chalabi Ammar
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons that results in progressive weakness and death from respiratory failure, commonly within about 3 years. Previous studies have shown association of a locus on chromosome 9p with ALS and linkage with ALS-frontotemporal dementia. We aimed to test whether this genomic region is also associated with ALS in an independent...
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