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Article

Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions.

Microbial cell factories - 30 Jun 2021

Zhou Jingru, Zhuang Yingping, Xia Jianye

Abstract excerpt

BACKGROUND: Genome-scale metabolic model (GSMM) is a powerful tool for the study of cellular metabolic characteristics. With the development of multi-omics measurement techniques in recent years, new methods that integrating multi-omics data into the GSMM show promising effects on the predicted results. It does not only improve the accuracy of phenotype prediction but also enhances the reliability of the model...

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PMID: 34193117
DOI: 10.1186/s12934-021-01614-2
PMCID: PMC8247156

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