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Article

Constraint-based models predict metabolic and associated cellular functions.

Nature reviews. Genetics - 1 Feb 2014

Bordbar Aarash, Monk Jonathan M, King Zachary A, Palsson Bernhard O

Abstract excerpt

The prediction of cellular function from a genotype is a fundamental goal in biology. For metabolism, constraint-based modelling methods systematize biochemical, genetic and genomic knowledge into a mathematical framework that enables a mechanistic description of metabolic physiology. The use of constraint-based approaches has evolved over ~30 years, and an increasing number of studies have recently combined...

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PMID: 24430943
DOI: 10.1038/nrg3643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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