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Article

OM-FBA: Integrate Transcriptomics Data with Flux Balance Analysis to Decipher the Cell Metabolism.

PloS one - 1 Jan 2016

Guo Weihua, Feng Xueyang

Abstract excerpt

Constraint-based metabolic modeling such as flux balance analysis (FBA) has been widely used to simulate cell metabolism. Thanks to its simplicity and flexibility, numerous algorithms have been developed based on FBA and successfully predicted the phenotypes of various biological systems. However, their phenotype predictions may not always be accurate in FBA because of using the objective function that is assumed...

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PMID: 27100883
DOI: 10.1371/journal.pone.0154188
PMCID: PMC4839607

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