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Article

Improving the phenotype predictions of a yeast genome-scale metabolic model by incorporating enzymatic constraints.

Molecular systems biology - 3 Aug 2017

Sánchez Benjamín J, Zhang Cheng, Nilsson Avlant, Lahtvee Petri-Jaan, Kerkhoven Eduard J, Nielsen Jens

Abstract excerpt

Genome-scale metabolic models (GEMs) are widely used to calculate metabolic phenotypes. They rely on defining a set of constraints, the most common of which is that the production of metabolites and/or growth are limited by the carbon source uptake rate. However, enzyme abundances and kinetics, which act as limitations on metabolic fluxes, are not taken into account. Here, we present GECKO, a method that enhances...

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Identifiers

PMID: 28779005
DOI: 10.15252/msb.20167411
PMCID: PMC5572397

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GEM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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