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Article

Hemophagocytic Lymphohistiocytosis in Adolescents and Young Adults: Genetic Predisposition and Secondary Disease.

The Medical clinics of North America - 1 Jan 2024

Vasco Alejandra Escobar, Talano Julie-Ann, Broglie Larisa

Abstract excerpt

Hemophagocytic lymphohistiocytosis (HLH) is a disorder of impaired immune regulation resulting in hyperinflammation that is ultimately fatal if not treated. HLH is categorized into familial disease, caused by genetic mutations affecting the function of cytotoxic T lymphocytes and natural killer cells, and secondary disease, triggered by infections, malignancies, rheumatologic disorders, or immune deficiency....

Topics

Humans
Adolescent
Young Adult
Lymphohistiocytosis, Hemophagocytic
Genetic Predisposition to Disease
Neoplasms
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37951650
DOI: 10.1016/j.mcna.2023.05.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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