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Article

Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis.

Hematology. American Society of Hematology. Education Program - 1 Jan 2015

Allen Carl E, McClain Kenneth L

Abstract excerpt

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by extreme immune activation, resulting in pathologic inflammation. The diagnosis includes a spectrum of inherited or acquired defects in cytotoxic lymphocyte function, often with uncontrolled infections. HLH may also arise as the result of persistent antigen stimulation due to autoimmune disease or malignancy. HLH is often described in binary...

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PMID: 26637718
DOI: 10.1182/asheducation-2015.1.177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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