Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population.

doi:10.1038/s41380-024-02489-6

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Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population.

Molecular psychiatry - 1 Sept 2024

Strom Nora I, Burton Christie L, Iyegbe Conrad, Silzer Talisa, Antonyan Lilit, Pool René, Lemire Mathieu, Crowley James J, Hottenga Jouke-Jan, Ivanov Volen Z, Larsson Henrik, Lichtenstein Paul, Magnusson Patrik, Rück Christian, Schachar Russell, Wu Hei Man, Cath Danielle, Crosbie Jennifer, Mataix-Cols David, Boomsma Dorret I, Mattheisen Manuel, Meier Sandra M, Smit Dirk J A, Arnold Paul D

Abstract excerpt

While 1-2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13-38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of OCS and its genetic relationship to OCD, we conducted the largest genome-wide association study (GWAS) meta-analysis of parent- or self-reported OCS to date...

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PMID: 38548983
DOI: 10.1038/s41380-024-02489-6
PMCID: PMC11420085

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