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Repression of Mammary Stem/Progenitor Cells by p53 Is Mediated by Notch and Separable from Apoptotic Activity

22 Oct 2010

Abstract excerpt

Breast cancer is the most common tumor among women with inherited mutations in the p53 gene (Li-Fraumeni syndrome). The tumors represent the basal-like subtype, which has been suggested to originate from mammary stem/progenitor cells. In mouse mammary epithelium, mammosphere-forming potential was increased with decreased dosage of the gene encoding the p53 tumor suppressor protein (Trp53). Limiting dilution...

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PMID: 21280161
DOI: 10.1002/stem.552

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