Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment.

Scientific reports - 9 Mar 2015

Zhang Pengju, Lo Alvin, Huang Yurong, Huang Ge, Liang Guozhou, Mott Joni, Karpen Gary H, Blakely Eleanor A, Bissell Mina J, Barcellos-Hoff Mary Helen, Snijders Antoine M, Mao Jian-Hua

Abstract excerpt

The interplay between host genetics, tumor microenvironment and environmental exposure in cancer susceptibility remains poorly understood. Here we assessed the genetic control of stromal mediation of mammary tumor susceptibility to low dose ionizing radiation (LDIR) using backcrossed F1 into BALB/c (F1Bx) between cancer susceptible (BALB/c) and resistant (SPRET/EiJ) mouse strains. Tumor formation was evaluated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Mice, Inbred BALB C

Share to Neoplasms, Radiation-Induced

Share to Quantitative Trait Loci

Share to Transforming Growth Factor beta1

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 25747469
DOI: 10.1038/srep08919
PMCID: PMC4352890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment.PMID 25747469Read ↗

Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility.Semantic proximity Read ↗

Multiple susceptibility loci for radiation-induced mammary tumorigenesis in F2[Dahl S x R]-intercross rats.Semantic proximity Read ↗

Murine Microenvironment Metaprofiles Associate with Human Cancer Etiology and Intrinsic SubtypesSemantic proximity Read ↗

Longitudinal multimodal characterization of radiation dermatitis in the C57BL/6J mouse modelSemantic proximity Read ↗

Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Cancer Latency and Affect Tumor TypeSemantic proximity Read ↗

Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk.Semantic proximity Read ↗

Two loci controlling susceptibility to radiation-induced lymphomagenesis on mouse chromosome 4: cdkn2a, a candidate for one locus, and a novel locus distinct from cdkn2a.Semantic proximity Read ↗

Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse.Semantic proximity Read ↗

Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.Semantic proximity Read ↗

Quantitative trait locus mapping of susceptibilities to butylated hydroxytoluene-induced lung tumor promotion and pulmonary inflammation in CXB mice.Semantic proximity Read ↗

siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.Semantic proximity Read ↗

BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.