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Article

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications

29 Oct 2021

Abstract excerpt

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of genes involved in cell proliferation, survival, angiogenesis, chemoresistance and immune responsiveness. In addition to these well-established oncogenic roles, STAT3...

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PMID: 34731785
DOI: 10.1016/j.neo.2021.10.003

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