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Building resilient health systems in Africa beyond the COVID-19 pandemic response

1 Jun 2021

Abstract excerpt

The inflammatory effects of IL-1α/β are controlled by IL-1R antagonist (IL-1Ra). One IL-1Ra isoform is secreted, whereas three other isoforms (intracellular IL-1Ra [icIL-1Ra] 1, 2, and 3) are supposed to remain intracellular because of the absence of a signal peptide. In contrast to the well-characterized function of the secreted isoform, the biological role of the intracellular isoforms remains largely unclear....

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PMID: 34183330
DOI: 10.1136/bmjgh-2021-006108

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