Article

Analysis of Anakinra therapy for the Deficiency of Interleukin-1 Receptor Antagonist through Clinical Evidence

2023-12-11

Abstract excerpt

Deficiency of interleukin-1 receptor antagonist (DIRA) is a rare life-threatening autosomal recessive autoinflammatory disease with symptoms including but not limited to osteomyelitis, periostitis, and systemic inflammation. DIRA is developed from the loss-of-function mutations of IL1RN gene that encodes IL-1 receptor antagonist (IL-1RA), leading to the unchecked pro-inflammatory signaling and subsequent systemic...

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Literature Corpus work: b2dec3d1-fe7f-552f-98e6-3021bed2afb7
DOI: 10.20944/preprints202312.0739.v1

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