Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients.

doi:10.1001/jamainternmed.2021.3108

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Article

Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients.

JAMA internal medicine - 1 Aug 2021

Van Driest Sara L, Abul-Husn Noura S, Glessner Joseph T, Bastarache Lisa, Nirenberg Sharon, Schildcrout Jonathan S, Eswarappa Meghana S, Belbin Gillian M, Shaffer Christian M, Mentch Frank, Connolly John, Shi Mingjian, Stein C Michael, Roden Dan M, Hakonarson Hakon, Cox Nancy J, Borinstein Scott C, Mosley Jonathan D

Abstract excerpt

Importance: Up to two-thirds of African American individuals carry the benign rs2814778-CC genotype that lowers total white blood cell (WBC) count. Objective: To examine whether the rs2814778-CC genotype is associated with an increased likelihood of receiving a bone marrow biopsy (BMB) for an isolated low WBC count. Design, Setting, and Participants: This retrospective genetic association study assessed African...

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Biopsy
Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Bone Marrow Examination

Duffy Blood-Group System

Genetic Profile

Leukocyte Count

Neutropenia

Receptors, Cell Surface

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Identifiers

PMID: 34180972
DOI: 10.1001/jamainternmed.2021.3108
PMCID: PMC8239990

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