Article
The African-Specific Variant in the Duffy Antigen Receptor for Chemokines Gene, CD8+ T-Cell Density, and Aggressive Breast Cancer Subtypes in Black Women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Sept 2025
Nair Nisha M, Mendicino Lucas, Fiorica Peter N, Omilian Angela R, Khoury Thaer, Bshara Wiam, Bandera Elisa V, Hong Chi-Chen, Abdou Yara, Freudenheim Jo L, Hennis Anselm J M, O'Brien Katie M, Zirpoli Gary R, Butler Ebonee N, Obafunwa John Oladapo, Weinberg Clarice R, Huo Dezheng, Li Bingshan, Guo Xingyi, Palmer Julie R, Haiman Christopher A, Zheng Wei, Yao Song, Ambrosone Christine B
Abstract excerpt
BACKGROUND: Immune response in blood varies by ancestry, linked to an African-specific variant (rs2814778) in the Duffy Antigen Receptor for Chemokines (DARC/ACKR1) gene. We examined associations between rs2814778, CD8+ T-cell density in breast tumors, and breast cancer risk in African-American/Black women. METHODS: CD8+ T-cell density in tumors from 428 Black women were examined in relation to the rs2814778...
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